PDE4B

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PDE4B
Available structures PDB Human UniProt search: PDBe RCSB showList of PDB id codes
Identifiers
Aliases	PDE4B, DPDE4, PDEIVB, phosphodiesterase 4B
External IDs	OMIM: 600127 MGI: 99557 HomoloGene: 1953 GeneCards: PDE4B
hideGene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 65,792,514 bp[1] End 66,374,579 bp[1]
showGene location (Mouse)
hideRNA expression pattern More reference expression data
showGene ontology
Orthologs
Species	Human	Mouse
Entrez	5142	18578
Ensembl	ENSG00000184588	ENSMUSG00000028525
UniProt	Q07343	n/a
RefSeq (mRNA)	showNM_001037339 NM_001037340 NM_001037341 NM_001297440 NM_001297441	showNM_001177980 NM_001177981 NM_001177982 NM_001177983 NM_019840
RefSeq (protein)	showNP_001032416 NP_001032417 NP_001032418 NP_001284369 NP_001284370	n/a
Location (UCSC)	Chr 1: 65.79 – 66.37 Mb	Chr 4: 102.09 – 102.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.^[5]

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5][6]

Clinical relevance

Altered activity of this protein has been associated with schizophrenia and bipolar disorder.^[5] PDE4B is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.^[7] PDE4B is involved in dopamine-associated and stress-related behaviours.^[8] It has also recently been found to modulate cognition, as reduction in PDE4B activity improves memory and long-term plasticity in mouse models, possibly supporting further therapeutic applications.^[9]

Inhibitors

AN2728, a boron-containing drug candidate that as of 2015 was under development by Anacor Pharmaceuticals for the topical treatment of psoriasis and atopic dermatitis (atopic eczema).^[10][11][12] mainly acting on PDE4B.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.