CDK5R1

From Wikipedia, the free encyclopedia

Jump to navigationJump to search

CDK5R1
Available structures PDB Ortholog search: PDBe RCSB showList of PDB id codes
Identifiers
Aliases	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
External IDs	OMIM: 603460 MGI: 101764 HomoloGene: 31200 GeneCards: CDK5R1
hideGene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 32,486,993 bp[1] End 32,491,253 bp[1]
showGene location (Mouse)
hideRNA expression pattern More reference expression data
showGene ontology
Orthologs
Species	Human	Mouse
Entrez	8851	12569
Ensembl	ENSG00000176749	ENSMUSG00000048895
UniProt	Q15078	P61809
RefSeq (mRNA)	NM_003885	NM_009871
RefSeq (protein)	NP_003876	NP_034001
Location (UCSC)	Chr 17: 32.49 – 32.49 Mb	Chr 11: 80.48 – 80.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.

Function

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.^[6]

In melanocytic cells CDK5R1 gene expression may be regulated by MITF.^[7]

Interactions

CDK5R1 has been shown to interact with:

• Actinin, alpha 1
• Amphiphysin,
• Beta-catenin,
• CAMK2A,
• CDK5RAP2,
• Cyclin-dependent kinase 5,
• Protein SET

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.